Burden of vascular risk factors by age, sex, ethnicity and deprivation in young adults with and without newly diagnosed type 2 diabetes
Authors' conclusion
The increased vascular risk phenotype associated with an earlier age of diagnosis of type 2 diabetes was consistent across ethnic and deprivation groups. Population-based strategies are needed to address the risk associated with early-onset type 2 diabetes, especially weight-management-based strategies.
Study context
- Population
- Individuals aged 16–50 years, Clinical Practice Research Datalink; 45.6% women among those with T2Dmatched cohort
- Participants
- 108,061 vs 829,946
- Exposure
- Newly diagnosed T2D vs no T2D
- T2Dn = 108,061
- Controlsn = 829,946reference
- Outcome
- Differences in BMI, obesity, LDL-C, HbA1c and hypertension between individuals with vs without T2D across sex, age, ethnicity and deprivation quintiles
Methodological detailspopulation-based, matched on sex, age and primary care practice (∼10 controls per case)
- Population-based
- Matched on sex, age and primary care practice (∼10 controls per case)
Main finding
As reported in the abstract
Vascular risk factors (T2D vs controls)
- BMI, obesity, LDL-C and hypertension were higher in individuals with vs without T2D
- Across both sexes, all ethnic groups and deprivation quintiles, differences were larger with an earlier age, particularly for BMI and obesity
- Association between age and HbA1c was variable across subgroups
- Differences in BMI, obesity and hypertension were largest in White individuals and with less deprivation
Observational data: associations, not effects.
Original publication
Burden of vascular risk factors by age, sex, ethnicity and deprivation in young adults with and without newly diagnosed type 2 diabetes. Diabetes Res Clin Pract. Published 10 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →