Brain insulin responsiveness is linked to age and peripheral insulin sensitivity
Authors' conclusion
We could show a region-specific relationship between brain insulin responsiveness, age and peripheral insulin sensitivity. Our findings underline the need to study brain insulin action in both men and women and further substantiate that brain insulin sensitivity is a possible link between systemic metabolism and neurocognitive functions.
Study context
- Population
- Participants aged 21–74 years, BMI 18–49 kg/m², 54 women54 women
- Participants
- 110 participants
- Comparison
- Intranasal insulin vs placebo; associations of age and peripheral insulin sensitivity with brain insulin action
- Outcome
- Brain insulin action (change in cerebral blood flow after intranasal insulin vs placebo) in predefined insulin-sensitive brain regions, associated with age and peripheral insulin sensitivity (OGTT)
Methodological detailsrandomized, placebo-controlled, within-subject design
- Randomized
- Placebo-controlled
- Within-subject design
Main finding
As reported in the abstract
Age vs insulin action in hippocampus (negative association)
β = −0.215
p = .017
Age vs insulin action in caudate nucleus (negative association)
β = −0.184
p = .047
Peripheral insulin sensitivity vs insulin action in amygdala (negative association)
β = −0.190
p = .023
Insular cortex: interaction between age and peripheral insulin sensitivity
β = −0.219 p = .005
Further findings
Sex differences
- Women showed the strongest negative association between age and hippocampal insulin action; men the strongest associations with peripheral insulin sensitivity and age in reward-related brain regions
Original publication
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