Bone proteins are associated with cardiovascular risk according to the SCORE2-Diabetes algorithm
Authors' conclusion
Sclerostin and periostin are associated with vascular risk in the SCORE2-Diabetes algorithm, opening a new line of investigation to identify novel biomarkers of cardiovascular risk in the type 2 diabetes population.
Study context
- Population
- Patients with T2D (62 ± 6 years, 60% males)
- Participants
- 104 patients
- Exposure
- Serum bioactive sclerostin and periostin vs cardiovascular disease (CVD) risk scales
- Outcome
- Association of bioactive sclerostin and periostin with CVD risk scales (FRS, REGICOR, SCORE2-Diabetes), focus on SCORE2-Diabetes 10-year CVD risk
Main finding
As reported in the abstract
Correlation with CVD risk scales
- Positive correlation of bioactive sclerostin with SCORE2-Diabetes
- p < 0.001
- Positive correlation of periostin with SCORE2-Diabetes
- p < 0.001
- Sclerostin and periostin significantly higher in high-very high risk (score ≥ 10%) than low-moderate risk (score < 10%)
- p < 0.001 for both
Observational data: associations, not effects.
Further findings
| Outcome | Bioactive sclerostin | Periostin | Combined model |
|---|---|---|---|
| Identification of high-very high vascular risk (ROC) | |||
| AUC | 0.696 | 0.749 | 0.795 |
| P | p = 0.001 | p < 0.001 | p < 0.001 |
| Sensitivity (> 131 pmol/L) | 51.6% | — not stated in the abstract | — not stated in the abstract |
| Specificity (> 131 pmol/L) | 78.6% | — not stated in the abstract | — not stated in the abstract |
| Sensitivity (> 1144 pmol/L) | — not stated in the abstract | 64.5% | — not stated in the abstract |
| Specificity (> 1144 pmol/L) | — not stated in the abstract | 76.2% | — not stated in the abstract |
— not stated in the abstract
Original publication
Bone proteins are associated with cardiovascular risk according to the SCORE2-Diabetes algorithm. Cardiovasc Diabetol. Published 24 August 2024. doi:10.
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