Body composition, metabolic syndrome, and lifestyle in treatment‐naïve gender‐diverse youth in Israel
Main finding · Body composition, MetS components and lifestyleResult — go to the resultOdds for MetS components 3.49 95% CI 1.63–7.44Authors' conclusion
Treatment-naïve transgender-male adolescents have an imbalance between muscle and adipose tissue, which places them at increased susceptibility for MetS components even prior to hormonal treatment.
Study context
- Population
- Treatment-naïve transgender youth attending The Israeli Children and Adolescents Gender Clinic, 6/2021–12/2022; median age 15.7 years
- Participants
- 153 participants
- Exposure
- Transgender males vs transgender females
- Transgender malesn = 94
- Outcome
- Body composition, MetS components and lifestyle
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Odds for metabolic syndrome (MetS) components
3.49
95% CI 1.63–7.44
P = 0.001
- Odds for MetS components increased per 1 SD decrease in muscle-to-fat ratio z-score
- 2.2 (95%CI: 1.45 to 3.26, p < 0.001)
- Did not meet any of the three lifestyle recommendations
- About one-third of the cohort
Observational data: associations, not effects.
Original publication
Body composition, metabolic syndrome, and lifestyle in treatment‐naïve gender‐diverse youth in Israel. Pediatr Obes. Published 18 August 2024. doi:10.
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