Body Composition, Adipocytokine, and Metabolic Parameters in Men With Congenital Hypogonadotropic Hypogonadism
Authors' conclusion
Patients with untreated CHH had impaired body composition, adipokines and metabolic parameters. While hormone therapies can improve body composition and glucolipid metabolism in patients with CHH, this imperfect treatment does not fully rescue body composition abnormalities when compared to healthy individuals. Abnormal metabolic parameters in patients with CHH are associated with increased fat mass and abnormal serum leptin level. Serum testosterone levels were independently negatively correlated with leptin levels.
Study context
- Population
- Adult men with congenital hypogonadotropic hypogonadism (CHH) and healthy controls66 CHH, 21 controls
- Exposure
- Treated vs untreated CHH vs healthy controls
- Outcome
- Body composition (DXA), adipokines and metabolic parameters
Main finding
As reported in the abstract
- Treated vs healthy controls: lower serum testosterone
- p < 0.001
- Treated vs healthy controls: increased body fat percentage (BFP) and visceral adipose tissue (VAT) volume, decreased lean soft tissue (LST) and bone mineral content (BMC)
- p < 0.05
- Treated vs healthy controls: increased leptin, decreased adiponectin
- p < 0.05
- Treated vs healthy controls: higher HOMA-IR, lower QUICKI
- p < 0.05
- Treated vs untreated: higher serum testosterone
- p < 0.001
- Treated vs untreated: decreased BFP and VAT volume, increased LST and BMC
- p < 0.05
- Treated vs untreated: decreased leptin
- p < 0.001
- Treated vs untreated: decreased HOMA-IR, increased QUICKI
- p < 0.05
- Treated: VAT volume, LST, BMC, HOMA-IR and QUICKI reached healthy control levels
- p > 0.05
Observational data: associations, not effects.
Further findings
Serum testosterone associations (multiple stepwise linear regression)
- Testosterone vs BFP
- β = −0.564, p < 0.001
- Testosterone vs VAT volume
- β = −0.260, p = 0.045
- Testosterone vs LST
- β = 0.305, p = 0.018
- Testosterone vs BMC
- β = 0.423, p = 0.001
- Testosterone vs leptin (independent)
- β = −0.277, p = 0.004
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →