Biomarkers and Diagnostic Thresholds for Congenital Hyperinsulinism
Authors' conclusion
This study suggests that a C-peptide concentration greater than 291.5 pmol/L is diagnostic of CHI in children. C-peptide appears to offer the greatest utility as a biochemical diagnostic test for CHI and could be prioritised for laboratory analysis.
Study context
- Population
- All children requiring hypoglycaemic screens at a quaternary children's hospital, 2009–2019
- Comparison
- Congenital Hyperinsulinism (CHI) vs non-CHI
- Outcome
- Diagnostic threshold value of C-peptide for CHI
Methodological detailssingle-centre, quaternary paediatrics unit
- Single-centre
- Quaternary paediatrics unit
Main finding
As reported in the abstract
C-peptide
CHI
147
median
non-CHI
72
median
P < 0.05
- Optimal C-peptide threshold (Youden Index) for detecting CHI
- 291.5 pmol/L
- Sensitivity at threshold
- 82%
- Specificity at threshold
- 99%
Observational data: associations, not effects.
Further findings
Insulin
P < 0.01
BOHB
P < 0.01
| Outcome | CHI | non-CHI | P value |
|---|---|---|---|
| FFA | median 0 | median 1910 μmol/L | P < 0.01 |
Original publication
Biomarkers and Diagnostic Thresholds for Congenital Hyperinsulinism. Clin Endocrinol (Oxf). Published 3 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →