Ovarian and Uterine Morphology in Minipuberty: Associations With Reproductive Hormones: a COPANA Study of 302 Girls
Authors' conclusion
Correlations between reproductive hormones and the number of antral follicles suggest that negative feedback in the female hypothalamic-pituitary-gonadal axis is established during minipuberty, with ovarian activity promoting uterine and glandular breast tissue growth. We provide normative data of infant ovarian and uterine morphology directly implementable to a clinical setting.
Study context
- Population
- Healthy infant girls at minipuberty, aged 3.4 months (SD 0.4)blood samples n = 269
- Participants
- 302 participants
- Primary endpoint
- Association between reproductive hormones and ovarian and uterine morphology by transabdominal US
- Follow-up
- Minipuberty
Primary result
As reported in the abstract
- Total follicle count vs ovarian volume
- r = 0.606; P < .001
- Total follicle count vs antimüllerian hormone (AMH)
- r = 0.378; P < .001
- Total follicle count vs inhibin B
- r = 0.251; P < .001
- Total follicle count vs follicle-stimulating hormone (FSH)
- r = −0.327; P < .001
- Follicles ≥5 mm vs AMH
- r = 0.264; P < .001
- Follicles ≥5 mm vs inhibin B
- r = 0.230; P = .002
- Follicles ≥5 mm vs E1
- r = 0.209; P = .004
- Follicles ≥5 mm vs E2
- r = 0.269; P < .001
- Follicles ≥5 mm vs progesterone (PROG)
- r = 0.160; P = .031
- Follicles ≥5 mm vs T
- r = 0.210; P = .004
- Follicles ≥5 mm vs FSH
- r = −0.183; P = .015
Further findings
Estrogens vs estrogen-responsive tissue size
- E2 vs uterine volume
- r = 0.134; P = .054
- E2 vs endometrial thickness
- r = 0.155; P = .020
- E1 vs mammary tissue diameter
- r = 0.213; P < .001
- E2 vs mammary tissue diameter
- r = 0.198; P < .001
Original publication
Ovarian and Uterine Morphology in Minipuberty: Associations With Reproductive Hormones: a COPANA Study of 302 Girls. J Clin Endocrinol Metab. Published 27 September 2024. doi:10.
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