Beyond the bias! Sex distribution in paediatric growth hormone deficiency reexamined
Authors' conclusion
Stratifying by sex, we found similar percentages of pituitary imaging abnormalities (including tumours) and the number of pituitary hormone deficiencies in boys and girls as the cause of GHD. For these classifications, we did not find the historically reported male sex predominance.
Study context
- Population
- Children referred for short stature; patients diagnosed with growth hormone deficiency (GHD) between 3 and 16 years of age
- Participants
- 5,880 short stature referrals
- Exposure
- Boys vs girls
- Boysn = 3,709
- Girlsn = 2,171reference
- Outcome
- Sex distribution of GHD cases by peak GH group, pituitary imaging results, and isolated GHD (IGHD) vs MPHD
Main finding
As reported in the abstract
Diagnosed with GHD among those tested
P < 0.001
Observational data: associations, not effects.
Further findings
Underwent provocative testing for GHD
P < 0.001
- Multiple pituitary hormone deficiencies (MPHD) · girls more likely, not significant
- P = 0.056
- MPHD · across peak GH (pGH) groups
- P = 0.06
Original publication
Beyond the bias! Sex distribution in paediatric growth hormone deficiency reexamined. Clin Endocrinol (Oxf). Published 11 March 2024. doi:10.
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