Baseline and longitudinal trajectories of body-mass index and all-cause mortality among patients with type 2 diabetes
Authors' conclusion
These findings suggest that while obesity itself may not be associated with an increased risk for mortality, weight gain, and in particular rapid weight gain, is a risk factor for mortality among patients with T2DM.
Study context
- Population
- T2D patients aged ≥40 years registered 2010–2015 in the Yinzhou Health Information System diabetes surveillance system, followed up until September 30, 2021
- Exposure
- 5-year body mass index (BMI) trajectories vs medium-stable BMI
- Outcome
- All-cause mortality
Methodological detailslatent class growth mixture model, Cox proportional hazards models
- Latent class growth mixture model
- Cox proportional hazards models
Main finding
As reported in the abstract
All-cause mortality by 5-year BMI trajectory
Each group vs medium-stableAdjusted hazard ratio (95% CI)
Early-increasing
1.21(1.02–1.43)
Late-sharp increasing
1.47(1.19–1.80)
Observational data: associations, not effects.
Further findings
Baseline BMI and all-cause mortality
- Nonlinear association; increased risk of death for low but not high BMI
- P for nonlinearity < 0.001
Original publication
Baseline and longitudinal trajectories of body-mass index and all-cause mortality among patients with type 2 diabetes. Diabetes Metab. Published 17 January 2023. doi:10.
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