Bariatric surgery and subsequent weight loss lead to a reversal of peripheral blood monocytosis in obesity
Authors' conclusion
Following bariatric surgery and the resulting weight loss, the obesity-associated perturbation of the monocyte compartment was largely reversed.
Study context
- Population
- Patients with obesity designated for bariatric surgery; 59.5% female, mean age 45.2±11.3 years, median body mass index (BMI) 48.4 kg/m²
- Participants
- 111 patients
- Exposure
- Before vs 6 and 12 months after bariatric surgery
- Outcome
- Monocyte counts and subpopulations after bariatric surgery
- Follow-up
- 6 and 12 months
Methodological detailslongitudinal, three time points: baseline, 6 and 12 months, COVID-19 containment measures resulted in a longitudinal reduction in the number of patient evaluations
- Longitudinal
- Three time points: baseline, 6 and 12 months
- COVID-19 containment measures resulted in a longitudinal reduction in the number of patient evaluations
Main finding
As reported in the abstract
6 and 12 months
- Absolute monocyte count decreased significantly within 12 months after surgery
- p = 0.0035
- CD14 surface expression increased in classical monocytes within 6 months
- p = 0.0272
- CD14 surface expression increased in intermediate monocytes within 6 months
- p = 0.0087
Observational data: associations, not effects.
Further findings
Weight loss
- Median weight loss
- 44.5 kg
Monocytes in obesity with T2D
- Total monocyte counts and non-classical monocyte numbers significantly higher in patients with obesity and T2D
Original publication
Bariatric surgery and subsequent weight loss lead to a reversal of peripheral blood monocytosis in obesity. Int J Obes (Lond). Published 24 April 2026. doi:10.
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