Automated Insulin Delivery Systems in Children and Adolescents With Type 1 Diabetes: A Systematic Review and Meta-analysis of Outpatient Randomized Controlled Trials
Pooled result · TIR (3.9-10 mmol/L)Result — go to the resultMD 11.38 % 95% CI 9.01–13.76Authors' conclusion
AID systems are more effective than conventional insulin therapy for children and adolescents with T1D in outpatient settings. The favorable effect is consistent both in the short term and long term.
Study context
- Population
- Outpatient children and adolescents with T1D
- Participants
- 1,345 children25 trials
- Comparison
- Automated insulin delivery (AID) systems vs conventional insulin therapy
- Outcome
- Percent time in range (TIR) (3.9-10 mmol/L)
Methodological detailsoutpatient RCTs
- Outpatient RCTs
Pooled result
TIR (3.9-10 mmol/L)
MD
11.38 %
95% CI 9.01–13.76
P < 0.001
AIDvs Conventional insulin therapy
MD 11.38 % (95% CI 9.01–13.76); P < 0.001
As reported in the abstract
Further pooled results
| Outcome | MD (%) (CI) | P value | |
|---|---|---|---|
| TIR, AID used over 3 months | 10.46 (8.71–12.20) | ||
| TIR, AID used over 6 months | 10.87 (7.11–14.63) | ||
| TBR (<3.9 mmol/L)Low certainty | −0.59 (−1.02 to −0.15) | P = 0.008 | |
| TAR (>10 mmol/L)High certainty | −12.19 (−14.65 to −9.73) | P < 0.001 | |
| −20−1001020Difference, % (linear scale) |
Original publication
Automated Insulin Delivery Systems in Children and Adolescents With Type 1 Diabetes: A Systematic Review and Meta-analysis of Outpatient Randomized Controlled Trials. Diabetes Care. Published 27 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →