Autoimmune Diabetes From Childhood to Adulthood: The Role of Pancreatic Autoantibodies and HLA-DRB1 Genotype
An erratum to this article was published (J Clin Endocrinol Metab, 18 Jan 2024 ↗)
Authors' conclusion
Autoimmunity and HLA-DRB1 genotype are age-dependent biomarkers. Adult-onset autoimmune diabetes is associated with lower genetic risk and lower immune response to pancreatic islet cells compared with early-onset diabetes.
Study context
- Population
- Patients with diabetes aged 11 months to 66 years; IAA, glutamate decarboxylase autoantibodies (GADA), IA2A, ZnT8A at diagnosis and HLA-DRB1 genotype analysed
- Participants
- 802 patients
- Exposure
- Early-onset vs adult-onset autoimmune diabetes; pancreatic autoantibodies and HLA-DRB1 genotype
- Outcome
- Pancreatic autoantibodies and HLA-DRB1 genotype by age at onset
- Follow-up
- Diagnosis
Main finding
As reported in the abstract
diagnosis
Age at onset with no HLA-DRB1 risk genotype (median, IQR 14.3-35.7)
27.5 years
Age at onset with high-risk HLA-DR3/DR4, significantly more common at lower age (median, IQR 7.1-21.6)
11.9 years
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Autoantibody–HLA-DRB1 associationsZnT8Avs DR4/non-DR3Association | 1.91 (1.15–3.17) | |
| Autoantibody–HLA-DRB1 associationsGADAvs DR3/non-DR4Association | 2.97 (1.55–5.71) | |
| Autoantibody–HLA-DRB1 associationsIA2Avs DR4/non-DR3Association | 3.89 (2.28–6.64) | |
| Autoantibody–HLA-DRB1 associationsIA2Avs DR3/DR4Association | 3.08 (1.83–5.18) | |
| 0.10.31310Odds ratio (log scale) |
Autoantibody–HLA-DRB1 associations
- No association of IAA with HLA-DRB1
Original publication
Autoimmune Diabetes From Childhood to Adulthood: The Role of Pancreatic Autoantibodies and HLA-DRB1 Genotype. J Clin Endocrinol Metab. Published 19 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →