Attainment of LDL-cholesterol target in high cardiovascular risk type 1 diabetic French people
Authors' conclusion
Control of LDL-c is highly insufficient in both HR and VHR patients. Cardiovascular risk evaluation and better control of risk factors may help decrease cardiovascular morbi-mortality in patients with type 1 diabetes.
Study context
- Population
- Hospitalized patients with T1D at high or very-high cardiovascular risk with fasting blood lipid analysis at admission; HR median age 37y, 64 % females; Very-high risk (VHR) median age 49 years, 42 % females
- Participants
- 85 vs 356
- Exposure
- HR vs VHR
- HRn = 85
- VHRn = 356
- Outcome
- Prevalence of LDL-C target attainment (VHR/HR: 1.4/1.8 mmol/l per 2019 guidelines; 1.8/2.6 mmol/l per 2016 guidelines)
- Follow-up
- Admission
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
LDL-C target attained
Observational data: associations, not effects.
Further findings
Treated with statins
Factors associated with LDL-C target attainment in HR (multivariable)
- Increasing age, OR
- 0.58 [0.38;0.89] (95% CI)
- BMI, OR
- 0.86 [0.75;0.98]
- HbA1c, OR
- 0.69 [0.50;0.94]
- Independently associated with lower odds of attainment
Factors associated with LDL-C target attainment in VHR
- Statin treatment, OR
- 2.33 [1.22;4.43]
- Secondary prevention, OR
- 2.33 [1.21;4.48]
- Chronic renal failure, OR
- 2.82 [1.42;5.61]
- Associated with higher odds of attainment
Original publication
Attainment of LDL-cholesterol target in high cardiovascular risk type 1 diabetic French people. Diabetes Metab. Published 3 August 2024. doi:10.
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