Associations of triglyceride-glucose (triglyceride and glucose (TyG)) index with chest pain incidence and mortality among the U.S. population
Main finding · Chest painResult — go to the resultOdds ratio 1.42 95% CI 1.14–1.77Authors' conclusion
The TyG index was positively linked to a higher incidence of chest pain. Moreover, the TyG index was associated with all-cause mortality not only in participants with chest pain but also in those without chest pain.
Study context
- Population
- US population, National Health and Nutrition Examination Survey (NHANES) 2001–2012, with or without chest pain
- Exposure
- TyG index quartile 4 vs quartile 1
- Outcome
- Chest pain; all-cause mortality in participants with or without chest pain
Methodological detailsNHANES 2001-2012, weighted logistic regression, weighted Cox proportional hazards models, restricted cubic spline analysis
- NHANES 2001-2012
- Weighted logistic regression
- Weighted Cox proportional hazards models
- Restricted cubic spline analysis
Main finding
Chest pain
Odds ratio
1.42
95% CI 1.14–1.77
P = 0.002
Quartile 4vs Quartile 1
OR 1.42 (95% CI 1.14–1.77); P = 0.002
As reported in the abstract
Observational data: associations, not effects.
Further findings
All-cause mortality · mean follow-up 139 months
- Deaths
- 2286 (27.43%)
- Adjusted HR per one-unit increase in TyG index, participants with chest pain
- 1.14 (95% CI = 0.94-1.37)
- Adjusted HR per one-unit increase in TyG index, participants without chest pain
- 1.25 (95% CI = 1.09-1.43)
- Nonlinear relationship between TyG index and all-cause mortality regardless of chest pain (all P for nonlinearity < 0.01)
Original publication
Associations of triglyceride-glucose (TyG) index with chest pain incidence and mortality among the U.S. population. Cardiovasc Diabetol. Published 30 March 2024. doi:10.
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