Associations of six insulin resistance-related indices with the risk and progression of cardio-renal-metabolic multimorbidity: evidence from the UK biobank
Authors' conclusion
In summary, IR-related indices, particularly TyG-WC, TyG-WHtR, and METS-IR, were observed to be associated with the presence and progression of CRM diseases. Their potential incorporation into risk assessment and prevention strategies, together with consideration of inflammatory and organ function pathways, might help reduce the burden of CRM multimorbidity; however, further prospective studies are needed to confirm these findings and clarify their clinical relevance.
Study context
- Population
- Cardio-renal-metabolic (CRM)-free participants from the UK BiobankCRM-free
- Participants
- 327,692 participants
- Exposure
- Six insulin resistance (IR)-related indices and CRM onset and progression
- Outcome
- CRM disease incidence and multistage progression (first, double, triple CRM diseases)
- Follow-up
- Mean 13.6 years
Methodological detailsUK Biobank, multistate modeling, mediation analysis
- UK Biobank
- Multistate modeling
- Mediation analysis
Main finding
As reported in the abstract
- Developed ≥1 CRM disease
- 17.3% (n = 58,563)
- TyG-waist circumference (TyG-WC) per 1-SD: increased risk of first CRM disease (all P < 0.001)
- 51.4%
- TyG-WC per 1-SD: increased risk of double CRM diseases (all P < 0.001)
- 88.6%
- TyG-WC per 1-SD: increased risk of triple CRM diseases (all P < 0.001)
- 128.7%
- TyG-waist-to-height ratio (TyG-WHtR) per 1-SD: increased risk of transition healthy → first CRM disease (all P < 0.001)
- 65.3%
- TyG-WHtR per 1-SD: increased risk of transition first → double (all P < 0.001)
- 34.6%
- TyG-WHtR per 1-SD: increased risk of transition double → triple (all P < 0.001)
- 26.7%
Observational data: associations, not effects.
Further findings
Predictive performance (AUC, net reclassification improvement (NRI), integrated discrimination improvement (IDI))
- TyG-WC, TyG-WHtR and metabolic score for insulin resistance (METS-IR) achieved the highest AUC, NRI and IDI values
Mediation analysis
- Systemic inflammation, organ function and especially kidney function partially mediated the associations
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →