Associations of relative fat mass and BMI with all‐cause mortality: Confounding effect of muscle mass
Authors' conclusion
In the general population, a higher RFM was significantly associated with mortality risk, whereas a higher BMI was not. Adjusting for total muscle mass increased the strength of associations of both RFM and BMI with all-cause mortality.
Study context
- Population
- Community-dwelling adults from the Dutch PREVEND general population cohort (1997–1998); mean age 49.8 years (range 28.8–75.7), 49.9% women
- Participants
- 8,433 adults
- Exposure
- Relative fat mass (RFM) vs BMI as predictors of all-cause mortality, with and without adjustment for muscle mass
- Outcome
- All-cause mortality
- Follow-up
- Median 18.4 years
Methodological detailsgeneral population cohort, community-dwelling adults
- General population cohort
- Community-dwelling adults
Main finding
As reported in the abstract
All-cause mortality, age- and sex-adjusted
Hazard ratio per 1-SD (95% CI)
RFMsignificant
1.16(1.09–1.24)
BMI
1.04(0.99–1.10)
- Deaths
- 1640 (19.4%)
Observational data: associations, not effects.
Further findings
All-cause mortality, additionally adjusted for muscle mass
| HR per 1-SD (95% CI) | ||
|---|---|---|
| RFM | 1.24 (1.16–1.32) | |
| BMI | 1.12 (1.06–1.19) | |
| 0.512Hazard ratio per 1-SD (log scale) |
Total muscle mass (24-h urinary creatinine excretion), age- and sex-adjusted
| Standardized beta (95% CI) | |
|---|---|
| RFM | 0.29 (0.27–0.31) |
| BMI | 0.38 (0.36–0.40) |
- Total muscle mass (24-h urinary creatinine excretion), age- and sex-adjusted — Association stronger with BMI than RFM; pdifference
- < 0.001
All-cause mortality, additionally adjusted for muscle mass
- Results were broadly similar in multivariable adjusted models
Original publication
Associations of relative fat mass and BMI with all‐cause mortality: Confounding effect of muscle mass. Obesity (Silver Spring). Published 10 January 2024. doi:10.
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