Lipids & metabolic liver disease
Associations of PM 2 .5 and Its Constituents With the Dynamic and Accelerated Progression of Cardiovascular‐Kidney‐Metabolic Syndrome: The Gold‐Health Cohort
Study context
- Population
- Older adults in the Guangzhou Older Longitudinal Dynamic Health (GOLD-Health) cohort, cardiovascular-kidney-metabolic (CKM) stages classified by American Heart Association guidelines1.49 million person-years
- Participants
- 41,175 / 266,016 / 206,692
- Exposure
- Exposure to PM2.5 and its five constituents
- CKM stage 0-1n = 41,175
- CKM stage 2n = 266,016
- CKM stage 3n = 206,692
- Outcome
- Dynamic CKM stage transitions (progression) and death
Methodological detailsmulti-state models, accelerated failure time models
- Multi-state models
- Accelerated failure time models
Main finding
As reported in the abstract
Each SD increase in organic matter (OM) exposure: acceleration in transition time from stage 2 to stage 3
22.1%
Observational data: associations, not effects.
Further findings
Accelerated CKM progression (accelerated failure time (AFT) models)
- Acceleration in transition time from stage 2 to stage 3 per SD increase in OM
- 22.1%
- Higher exposure associated with accelerated CKM progression; OM strongest effects across most transitions
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Associations of PM 2 .5 and Its Constituents With the Dynamic and Accelerated Progression of Cardiovascular‐Kidney‐Metabolic Syndrome: The Gold‐Health Cohort. Diabetes Obes Metab. Published 5 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →