Associations of Plasma and Fecal Metabolites with Body Mass Index and Body Fat Distribution in Children
Authors' conclusion
Plasma and fecal metabolites such as glutamine may serve as potential therapeutic targets for the development of obesity.
Study context
- Population
- Healthy children aged 6 to 9 years in China; 186 girls and 238 boys; body fat by DXA
- Participants
- 424 children
- Outcome
- Association of plasma and fecal metabolites with body mass index (BMI), BMI for age Z score (BMIZ) and body fat distribution
Methodological detailstargeted metabolomics
- Targeted metabolomics
Main finding
As reported in the abstract
Associations of plasma and fecal metabolites with BMI, BMIZ and body fat distribution (multiple linear regression, adjusted, FDR-corrected)
- Metabolites quantified
- 200 plasma and 212 fecal
- Metabolites associated with different weight statuses (OPLS-DA and random forest)
- 9 plasma and 11 fecal
- Plasma metabolites negatively associated (fumaric acid, glycine, l-glutamine, methylmalonic acid, succinic acid)
- β −1.373 to −.016, pFDR < 0.001-0.031
- Fecal metabolite negatively associated (protocatechuic acid)
- β −1.008 to −.071, pFDR 0.005-0.033
- Plasma metabolites positively associated (isovaleric acid, isovalerylcarnitine, l-glutamic acid, pyroglutamic acid)
- β .023-2.396, pFDR < 0.001
- Fecal metabolites positively associated (3-aminoisobutanoic acid, butyric acid, N-acetylneuraminic acid, octanoylcarnitine, oleoylcarnitine, palmitoylcarnitine, stearoylcarnitine, taurochenodesoxycholic acid, taurodeoxycholic acid)
- β .014-1.736, pFDR < 0.001-0.049
Observational data: associations, not effects.
Original publication
Associations of Plasma and Fecal Metabolites with Body Mass Index and Body Fat Distribution in Children. J Clin Endocrinol Metab. Published 4 May 2024. doi:10.
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