Associations of estimated glucose disposal rate with frailty progression: results from two prospective cohorts
Authors' conclusion
Regardless of diabetes or not, a higher level of eGDR was associated with the decelerated frailty progression. Our findings highlight the role of eGDR in frailty progression and recommend taking effective interventions to improve eGDR for preventing frailty progression.
Study context
- Population
- Middle-aged and older adults from China Health and Retirement Longitudinal Study (CHARLS) (n 8872; mean age 58.9 years, 53.3% female) and Health and Retirement Study (HRS) (n 5864; mean age 67.0 years, 59.0% female)two cohorts
- Exposure
- Upper vs lower tertile of estimated glucose disposal rate (eGDR)
- Outcome
- Frailty progression: repeated measurements of frailty index (FI, 0–100) assessed every two years
- Follow-up
- Median 7.0 years (CHARLS) and 12.8 years (HRS)
Methodological detailstwo prospective cohorts (CHARLS and HRS), linear mixed-effect models
- Two prospective cohorts (CHARLS and HRS)
- Linear mixed-effect models
Main finding
As reported in the abstract
FI progression, T3 vs T1 of eGDR
β
−0.294
95% CI −0.390 to −0.198P < 0.001
CHARLS; decelerated frailty index (FI) progression with T3
β
−0.378
95% CI −0.474 to −0.281P < 0.001
HRS; decelerated FI progression with T3
Observational data: associations, not effects.
Further findings
FI progression per 1 SD increase in continuous eGDR
- CHARLS β
- −0.142 (95% CI −0.181 to −0.103, P < 0.001)
- HRS β
- −0.170 (95% CI −0.209 to −0.130, P < 0.001)
Sensitivity and subgroup analyses
- Associations still observed after excluding baseline frail participants
- Associations consistent among participants with and without diabetes
Original publication
Associations of estimated glucose disposal rate with frailty progression: results from two prospective cohorts. Cardiovasc Diabetol. Published 19 February 2025. doi:10.
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