Associations of Diabetes and Prediabetes With Mortality and Life Expectancy in China: A National Study
Authors' conclusion
In this national study, diabetes and prediabetes were significantly associated with reduced life expectancy and increased all-cause and cause-specific mortality risks. The disparities in excess mortality associated with diabetes and prediabetes between different ages and residences have implications for diabetes and prediabetes prevention and treatment programs.
Study context
- Population
- Adults aged ≥18 years from the general population in China; 10.5% had diabetes and 36.2% prediabetes in 2013
- Participants
- 135,405 adults
- Exposure
- Diabetes and prediabetes vs normoglycemia
- Outcome
- Excess mortality (all-cause and cause-specific) and life-years lost
- Follow-up
- Median 6 years
Methodological detailsnational, general population
- National
- General population
Main finding
As reported in the abstract
All-cause mortality
Diabetes
1428
events
Prediabetes
2300
events
Each group vs normoglycemiaAdjusted relative risk (95% CI)
Diabetes
1.61(1.49–1.73)
Prediabetes
1.08(1.01–1.15)
- Total deaths
- 5517
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted RR (95% CI) | |
|---|---|---|
| CVD mortalityDiabetesvs Normoglycemia | 1.59 (1.41–1.78) | |
| CVD mortalityPrediabetesvs Normoglycemia | 1.10 (1.00–1.21) | |
| 0.512Adjusted relative risk (log scale) |
| Outcome | Difference (years) |
|---|---|
| Life expectancy at age 40 yearsDiabetes vs Normoglycemia · shorter with Diabetes | 4.2 |
| Life expectancy at age 40 yearsPrediabetes vs Normoglycemia · shorter with Prediabetes | 0.7 |
Other cause-specific mortality
- Diabetes significantly associated with increased risk of death from cancer, respiratory disease, liver disease, and DKA or coma
- Associations with all-cause and CVD mortality varied by age and residence
Original publication
Associations of Diabetes and Prediabetes With Mortality and Life Expectancy in China: A National Study. Diabetes Care. Published 10 September 2024. doi:10.
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