Associations of body roundness index with cardiovascular disease and mortality among patients with metabolic syndrome
Authors' conclusion
BRI might be a more reliable predictor of cardiovascular outcomes and mortality in MetS patients than BMI. The identified threshold value of BRI can assist clinicians in making accurate prognostic evaluations. However, findings may vary by age and gender, underscoring the need for further research in diverse populations.
Study context
- Population
- US adults with metabolic syndrome (MetS), National Health and Nutrition Examination Surveys (NHANES) 2001–2016
- Participants
- 10,527 adults
- Exposure
- Body roundness index (BRI) quartiles
- Outcome
- CVD prevalence, all-cause mortality and cardiovascular-specific mortality
Methodological detailsnationally representative, NHANES 2001-2016
- Nationally representative
- NHANES 2001-2016
Main finding
As reported in the abstract
Higher BRI quartiles and increased cardiovascular disease (CVD) prevalence, OR [CI]
1.56
1.32–1.84p < 0.001
U-shaped relationship of BRI with all-cause and cardiovascular mortality (fully adjusted); threshold value
6.89
p for non-linear ≤0.001
Above threshold, per unit BRI: cardiovascular mortality HR [CI]
1.09
1.02–1.15p = 0.006
Above threshold, per unit BRI: overall mortality HR [CI]
1.08
1.04–1.12p < 0.001
Observational data: associations, not effects.
Further findings
- Body mass index (BMI) showed a paradoxical relationship with reduced mortality risk in unadjusted models, insignificant after adjustment
- P = 0.195; 0.144
Original publication
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