Associations of lipoprotein subclasses with risk of all‐cause and cardiovascular disease mortality in individuals with type 2 diabetes: A prospective cohort study
Authors' conclusion
The associations between lipoprotein particles, particularly HDL particles, with all-cause and CVD mortality among patients with type 2 diabetes were significantly varied by particle sizes, highlighting the importance of particle size as a lipoprotein metric in mortality risk discrimination.
Study context
- Population
- Individuals with T2D from the UK Biobank
- Participants
- 6,575 individuals
- Exposure
- HR per SD increment of log-transformed lipoprotein subclasses
- Outcome
- All-cause and CVD mortality
- Follow-up
- Median 11.4 years
Methodological detailsUK Biobank, quantitative nuclear magnetic resonance, multivariable-adjusted Cox regression, false discovery rate-adjusted p-values
- UK Biobank
- Quantitative nuclear magnetic resonance
- Multivariable-adjusted Cox regression
- False discovery rate-adjusted p-values
Main finding
As reported in the abstract
Small high-density lipoprotein (HDL) particles, HR (95% CI) per SD
0.78
0.69, 0.87
Very large HDL particles, HR (95% CI) per SD
1.28
1.12, 1.45
Large HDL particles, HR (95% CI) per SD
1.19
1.05, 1.35
Observational data: associations, not effects.
Further findings
All-cause mortality (943 deaths) · median follow-up 11.4 years
- Small HDL particle, HR
- 0.79, 0.74-0.85 (95% CI)
- Large HDL particle, HR
- 1.15, 1.07-1.24 (95% CI)
- Very large HDL particle, HR
- 1.26, 1.17-1.36 (95% CI)
Very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) particles
- Very small VLDL particle positively, medium LDL particle inversely associated with all-cause mortality; neither associated with cardiovascular disease (CVD) mortality
Cholesterol and TG within lipoprotein particles
- Association pattern similar to that of the lipoprotein particles themselves
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →