Associations of General Adiposity, Abdominal Adiposity, and Their Changes With Fracture Risk in Chinese Individuals With Type 2 Diabetes: A Population-Based Cohort Study in Hong Kong
Authors' conclusion
In individuals with type 2 diabetes, general adiposity showed site-specific associations with fracture risk, with its longitudinal changes demonstrating U-shaped relationships, whereas abdominal adiposity and its increases were independently associated with higher fracture risk.
Study context
- Population
- Individuals with T2D who underwent structured assessments in the Hong Kong Hospital Authority, August 2001–February 2022; mean ± SD age 61.9 ± 11.8 years, median diabetes duration 1 [0–6] years, 53.1% men247,540 with 2-year measurements
- Participants
- 436,929 individuals
- Exposure
- Baseline BMI, waist circumference and their 2-year percentage changes and fracture risk
- Outcome
- Incident any-site, major osteoporotic and site-specific fractures
- Follow-up
- Median 8.3 years
Methodological detailsmultivariable Cox regression, restricted cubic spline analyses
- Multivariable Cox regression
- Restricted cubic spline analyses
Main finding
As reported in the abstract
Underweight: higher risks of any-site, major osteoporotic, hip and pelvis fractures
30-77%
Class II obesity: higher risks of humerus, upper leg and ankle fractures
21-36%
Weight change: U-shaped associations with any-site, major osteoporotic, hip and humerus fractures; lowest risks at weight change of
−1.5% to 2.3%
Observational data: associations, not effects.
Original publication
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