Associations of cumulative exposure and dynamic trajectories of the cholesterol–HDL–glucose index and its obesity-related derivatives with cardiovascular disease: a nationwide prospective cohort study
Authors' conclusion
CHG and its derivatives were strongly associated with incident CVD, with CHG-CVAI and CHG-WC exhibiting the most pronounced associations. Moreover, ascending and declining trajectories of CHG-CVAI and CHG-WC were linked to higher risk
Study context
- Population
- Cardiovascular disease (CVD)-free participants from the China Health and Retirement Longitudinal Study (CHARLS)CVD-free at baseline
- Participants
- 3,359 participants
- Exposure
- Cumulative exposure and trajectories of CHG and its obesity-related derivatives (CHG-WC, CHG-CVAI) and incident CVD
- Outcome
- Incident CVD
- Follow-up
- Median 5 years
Methodological detailsnationwide, repeated measurements (2011 and 2015)
- Nationwide
- Repeated measurements (2011 and 2015)
Main finding
As reported in the abstract
HR
- Stable high · CHG-CVAI
- 1.79
- Stable high · CHG-WC
- 1.65
- Ascending · CHG-CVAI
- 1.79
- Declining · CHG-CVAI
- 1.54
- Ascending · CHG-WC
- 1.45
- Declining · CHG-WC
- 1.54
- Incident CVD
- 466 participants (13.9%)
- Cumulative CHG-WC and CVD
- HR = 1.29
- Cumulative CHG-CVAI and CVD
- HR = 1.28
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Discriminative power: cumulative CHG derivatives vs isolated cumulative CHG | Delong's test P < 0.05 |
Discriminative power: cumulative CHG derivatives vs isolated cumulative CHG
- Cumulative CHG derivatives showed significantly better discriminative power than isolated cumulative CHG
Original publication
Associations of cumulative exposure and dynamic trajectories of the cholesterol–HDL–glucose index and its obesity-related derivatives with cardiovascular disease: a nationwide prospective cohort study. Cardiovasc Diabetol. Published 17 July 2026. doi:10.
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