Associations between serum per- and polyfluoroalkyl substance concentrations and β-cell function and insulin resistance in adult females
Authors' conclusion
In this cross-sectional analysis, exposure to certain legacy, alternative, and precursor PFAS were associated with β-cell dysfunction.
Study context
- Population
- Adult female participants of the 2018–2021 follow-up of the Maternal-Infant Research on Environmental Chemicals (MIREC) study
- Participants
- 274 participants
- Exposure
- Serum PFAS concentrations and β-cell function and insulin resistance
- Outcome
- Composite measures of β-cell function (PI:INS and PI:CP ratios) and insulin resistance (HOMA-IR and TyG index)
Methodological detailsfollow-up of the MIREC study
- Follow-up of the MIREC study
Main finding
As reported in the abstract
PI:INS ratio
Increase in PI:INS ratio per doubling of Σ7PFAS, PFOS and PFHxS
5-9%
Observational data: associations, not effects.
Further findings
- Inverse associations between Σ7PFAS and HOMA-IR and fasting insulin
- Many results were of small magnitude or imprecise
Original publication
Associations between serum per- and polyfluoroalkyl substance concentrations and β-cell function and insulin resistance in adult females. J Clin Endocrinol Metab. Published 19 January 2026. doi:10.
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