Associations between perceived stress and glycemic measures: gender and age as moderators
Authors' conclusion
Gender moderated the associations between perceived stress and both prediabetes prevalence and 2h-PG levels. Among women, age further moderated the association between perceived helplessness and these outcomes. Future research should consider both moderators. Tailored psychosocial stress management strategies may help reduce the prevalence of prediabetes and diabetes.
Study context
- Population
- Diabetes-free adults in Singapore
- Participants
- 470 adults
- Exposure
- Perceived stress (perceived helplessness, perceived self-efficacy) and glycemic measures, with gender and age as moderators
- Outcome
- Association of perceived stress with prediabetes and 2h-PG; gender and age as moderators
Main finding
As reported in the abstract
- Gender significantly moderated the relationship between perceived stress factors and both prediabetes status and 2h-PG levels
- Men: higher perceived helplessness and perceived self-efficacy significantly associated with lower prevalence of prediabetes and lower 2h-PG
- Women: these associations were non-significant
- Women: age significantly moderated the relationship of perceived helplessness (not perceived self-efficacy) with prediabetes and 2h-PG
- Younger women: higher perceived helplessness associated with greater prevalence of prediabetes and higher 2h-PG
- Multivariable regression analyses
Observational data: associations, not effects.
Original publication
Associations between perceived stress and glycemic measures: gender and age as moderators. BMJ Open Diabetes Res Care. Published 4 November 2025. doi:10.
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