Associations between insulin resistance indices and cardiovascular disease in older adults with cardiovascular-kidney-metabolic syndrome stage 0–3: The GOLD-Health cohort
Authors' conclusion
All eight IR indices can predict CVD in older adults at CKM stage 0-3, with TyG-WC showing optimal predictive performance.
Study context
- Population
- Older adults with cardiovascular-kidney-metabolic (CKM) syndrome stages 0–3, Guangzhou Older Longitudinal Dynamic Health (GOLD-Health) cohort
- Participants
- 463,545 adults
- Exposure
- Highest vs lowest quartile of eight insulin resistance (IR) indices
- Outcome
- Incident CVD
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
- Highest quartile
- HR, TyG 1.150; P ≤ 0.001
- Highest quartile
- HR, TyG-BMI 1.116; P ≤ 0.001
- Highest quartile
- HR, TyG-WC 1.190; P ≤ 0.001
- Highest quartile
- HR, TyG-WHtR 1.177; P ≤ 0.001
- Highest quartile
- HR, LAP 1.130; P ≤ 0.001
- Highest quartile
- HR, AIP 1.142; P ≤ 0.001
- Highest quartile
- HR, VAI 1.114; P ≤ 0.001
- Highest quartile
- HR, CVAI 1.186; P ≤ 0.001
- Incident cardiovascular disease (CVD) cases
- 14,414 (10.51/1000 person-years)
Observational data: associations, not effects.
Further findings
Predictive capacity for CVD (ROC)
- Highest AUC: TyG-WC
- 0.763
Subgroups by CKM stage
- Stronger associations in CKM stage 3
Original publication
Associations between insulin resistance indices and cardiovascular disease in older adults with cardiovascular-kidney-metabolic syndrome stage 0–3: The GOLD-Health cohort. Diabetes Res Clin Pract. Published 13 June 2025. doi:10.
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