Associations Between Glucose Metabolism Measures and Amyloid-β and Tau Load on Positron Emission Tomography (PET) 14 Years Later: Findings From the Framingham Heart Study
Authors' conclusion
Our findings suggest that glucose metabolism is associated with increased future tau but not amyloid-β load. This provides relevant knowledge for prevention strategies and prognostics to improve health care.
Study context
- Population
- Adults without dementia from the Framingham Heart Study; mean age 43.1 years (SD 10.7, range 20–70)
- Participants
- 288 adults
- Exposure
- Glucose metabolism measures (FPG, insulin, homeostatic model assessment for insulin resistance (HOMA-IR)) vs amyloid-β and tau load on PET 14 years later
- Outcome
- Amyloid-β or tau load on PET
- Follow-up
- 14 years later
Methodological detailslinear regression, FDR correction
- Linear regression
- FDR correction
Main finding
As reported in the abstract
Tau load on PET
Elevated plasma glucose (>100 mg/dL) and greater tau load: B
0.03 (0.01-0.05), P = 0.024 after FDR correction (95% CI)
Observational data: associations, not effects.
Further findings
Effect modification by APOE ε4 carriership (glucose–tau)
- APOE ε4 carriership modified association: B
- −0.08 (−0.12 to −0.03), P = 0.001 (95% CI)
- Association present only in APOE ε4 noncarriers (n = 225)
Plasma insulin and HOMA-IR · 14 years later
- Plasma insulin and HOMA-IR not associated with amyloid-β or tau load after FDR correction
Original publication
Associations Between Glucose Metabolism Measures and Amyloid-β and Tau Load on PET 14 Years Later: Findings From the Framingham Heart Study. Diabetes Care. Published 30 July 2024. doi:10.
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