Gestational diabetes & diabetes in pregnancy
Associations between gestational diabetes and cardiovascular disease largely operate independently of postpartum causal pathways: A population‐based cohort study in England
Main finding · CVDResult — go to the resultAdjusted hazard ratio 1.58 95% CI 1.27–1.97Authors' conclusion
These findings emphasise the need for comprehensive cardio metabolic screening following a pregnancy affected by GDM.
Study context
- Population
- Women with and without gestational diabetes mellitus (GDM), England (ELOPE-GDM study)records, matched cohort
- Participants
- 43,572 vs 174,288
- Exposure
- GDM vs non-GDM
- GDMn = 43,572
- Non-GDMn = 174,288reference
- Outcome
- CVD
Methodological detailscausal mediation analysis
- Causal mediation analysis
Main finding
As reported in the abstract
Adjusted hazard ratio
1.58
95% CI 1.27–1.97
GDMvs Non-GDM
aHR 1.58 (95% CI 1.27–1.97)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| IHD | aHR 1.83 (CI 1.35–2.49) | |
| Stroke/TIA | aHR 1.43 (CI 1.06–1.95) | |
| Postpartum T2D, hypertension, dyslipidaemia or any of theseGDMvs Non-GDM | OR (T2D) 13.90 (95% CI 13.19–14.51) | |
| Postpartum T2D, hypertension, dyslipidaemia or any of theseGDMvs Non-GDM | OR (hypertension) 1.87 (95% CI 1.781–1.92) | |
| Postpartum T2D, hypertension, dyslipidaemia or any of theseGDMvs Non-GDM | OR (dyslipidaemia) 1.80 (95% CI 1.76–1.84) | |
| Postpartum T2D, hypertension, dyslipidaemia or any of theseGDMvs Non-GDM | OR (any mediator) 1.67 (95% CI 1.63–1.71) | |
| 0.050.21520Ratio (log scale) |
Proportion of GDM effect on cardiovascular disease (CVD) mediated by postpartum conditions
- Mediated by T2D
- 36% (95% CI 8%-64%)
- Mediated by hypertension (5%-24%)
- 15%
- Mediated by dyslipidaemia (18%-55%)
- 37%
- Mediated by a combination (11%-53%)
- 32%
- Most of the effect of GDM on CVD not attributed to these mediators
Original publication
Associations between gestational diabetes and cardiovascular disease largely operate independently of postpartum causal pathways: A population‐based cohort study in England. Diabetes Obes Metab. Published 5 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →