Associations between decreases in adiposity and reductions in HbA1c and insulin use in the Look AHEAD cohort
Authors' conclusion
Reductions in adiposity are associated with stabilized and slightly lower HbA1c and a marked reduction in the need for insulin therapy. These benefits generalize across clinical subgroups.
Study context
- Population
- Adults aged 45–76 years with T2D and overweight or obesity enrolled in the Look AHEAD weight-loss trial
- Participants
- 1,316 adults
- Exposure
- 5% decreases in adiposity measures
- Outcome
- HbA1c and insulin use over time in relation to 5% decreases in adiposity measures
- Follow-up
- 8 years
Methodological detailssecondary analysis of the Look AHEAD randomised trial, 8-year follow-up, generalized linear models
- Secondary analysis of the Look AHEAD randomised trial
- 8-year follow-up
- Generalized linear models
Main finding
As reported in the abstract
Mean HbA1c per 5% reduction in adiposity · over 8 years
Lower mean HbA1c per 5% reduction in total percent fat
0.15%
95% CI 0.12%–0.18%
Lower mean HbA1c per 5% reduction in waist circumference
0.16%
95% CI 0.13%–0.19%
Lower mean HbA1c per 5% reduction in BMI
0.13%
95% CI 0.11%–0.16%
Lower odds of insulin use over time, from 5% reduction in percent body fat to 5% reductions in waist circumference and BMI
21% to 32% lower odds
Observational data: associations, not effects.
Further findings
- Associations evident across subgroups defined by sex, diabetes duration, obesity status and intervention assignment
Original publication
Associations between decreases in adiposity and reductions in HbA1c and insulin use in the Look AHEAD cohort. Obesity (Silver Spring). Published 4 February 2025. doi:10.
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