The association of triglyceride-glucose and triglyceride-glucose related indices with the risk of heart disease in a national cohort study
An erratum to this article was published (Cardiovasc Diabetol, 19 Apr 2025 ↗)
Authors' conclusion
In the national population study, higher TyG-BMI, TyG-WC, and TyG-WHtR indices were significantly associated with an increased risk of heart disease, with TyG-BMI and TyG-WC showing stronger correlations. While this association was evident in non-T2D patients, only TyG-BMI was associated with heart disease incidence in T2D patients, underscoring the necessity for further investigation.
Study context
- Population
- Participants of the China Health and Retirement Longitudinal Study (CHARLS), overall and by T2D or non-T2D status
- Participants
- 7,945 participants
- Exposure
- Highest vs lowest quartile of triglyceride-glucose (TyG) and TyG-related indices
- Outcome
- Incidence of heart disease
- Follow-up
- 9-year follow-up
Methodological detailsnational cohort (CHARLS), multivariate Cox proportional hazards models, restricted cubic spline, subgroup and sensitivity analyses
- National cohort (CHARLS)
- Multivariate Cox proportional hazards models
- Restricted cubic spline
- Subgroup and sensitivity analyses
Main finding
As reported in the abstract
- Developed heart disease
- 1477 participants (18.6%)
Observational data: associations, not effects.
Further findings
Heart disease in non-diabetic patients · 9-year follow-up
- TyG-BMI, adjusted HR
- 1.75 (95% CI 1.47-2.08)
- TyG-WC, adjusted HR
- 1.47 (95% CI 1.24-1.75)
- TyG-WHtR, adjusted HR
- 1.34 (95% CI 1.13-1.60)
- Associations consistent with all participants
Heart disease in diabetes patients · 9-year follow-up
- Highest quartile of TyG-BMI, HR
- 1.86 (95% CI 1.02-3.40)
- No significant associations of TyG, TyG-WC, TyG-WHtR with heart disease risk
Original publication
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