Association of remnant cholesterol inflammation index with future cardiovascular disease risk in patients with cardiovascular-kidney-metabolic syndrome stages 0–3
Main finding · Future CVDResult — go to the resultHazard ratio 1.25 95% CI 1.03–1.52Authors' conclusion
Among individuals with CKM syndrome stages 0-3, elevated RCII levels were associated with future risk of CVD.
Study context
- Population
- Participants with cardiovascular-kidney-metabolic (CKM) syndrome stages 0–3 and without prior cardiovascular diseases (CVD), China Health and Retirement Longitudinal Study
- Participants
- 7,527 participants
- Exposure
- Highest vs lowest quartile of remnant cholesterol inflammation index (RCII)
- Outcome
- CVD
- Follow-up
- Median 7 years
Methodological detailsChina Health and Retirement Longitudinal Study
- China Health and Retirement Longitudinal Study
Main finding
Future CVD
Hazard ratio
1.25
95% CI 1.03–1.52
P = 0.009 for trend
Highest quartilevs Lowest quartile
HR 1.25 (95% CI 1.03–1.52); P for trend = 0.009
As reported in the abstract
Observational data: associations, not effects.
Further findings
CVD events (overall) · median follow-up 7 years
- Participants with CVD events
- 1,247 (16.5%)
Optimal dichotomous RCII cutoff for CVD (Kaplan-Meier)
- Optimal cutoff of RCII
- 1.488 (log-rank P < 0.05)
Mediation of remnant cholesterol (RC)–CVD association by hs-CRP
- RC and hs-CRP synergistic effect on CVD; hs-CRP partially mediated RC–CVD association, proportion mediated
- 18.87% (P = 0.040)
Original publication
Association of remnant cholesterol inflammation index with future cardiovascular disease risk in patients with cardiovascular-kidney-metabolic syndrome stages 0–3. Diabetes Res Clin Pract. Published 7 February 2026. doi:10.
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