Association of Urinary Nitrate With Diabetes Complication and Disease-Specific Mortality Among Adults With Hyperglycemia
Authors' conclusion
Higher urinary nitrate is associated with lower risk of congestive heart failure and diabetic nephropathy, and lower risk of all-cause, CVD, and diabetes mortalities. These findings indicate that inorganic nitrate supplementation can be considered as a supplementary treatment for people with hyperglycemia.
Study context
- Population
- People with hyperglycemia in the National Health and Nutrition Examination Survey 2005–2014
- Participants
- 6,208 people
- Exposure
- Highest vs lowest tertile of urinary nitrate
- Outcome
- Diabetes complications (congestive HF, coronary heart disease, angina, stroke, MI, DR, nephropathy) and disease-specific mortality
Methodological detailsNHANES 2005–2014, linked to National Death Index
- NHANES 2005–2014
- Linked to National Death Index
Main finding
As reported in the abstract
Highest tertile vs Lowest tertileEstimate (95% CI)
Congestive HF
OR 0.41(0.27–0.60)
Diabetic nephropathy
OR 0.50(0.41–0.62)
All-cause mortality
HR 0.78(0.62–0.97)
CVD mortality
HR 0.56(0.37–0.84)
Diabetes mortality
HR 0.47(0.24–0.90)
- Dose-dependent linear relationships for all-cause, cardiovascular disease (CVD) and diabetes mortality
- P for nonlinearity > 0.05
- No association between nitrate and cancer mortality
- 1.13; 0.71-1.80 (HR; 95% CI)
Observational data: associations, not effects.
Original publication
Association of Urinary Nitrate With Diabetes Complication and Disease-Specific Mortality Among Adults With Hyperglycemia. J Clin Endocrinol Metab. Published 28 December 2022. doi:10.
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