Association of the triglyceride-glucose (TyG) index with prognosis in surgical intensive care patients: data from the MIMIC-IV
Authors' conclusion
An increasing risk of mortality was related to an elevated TyG index. In critically ill patients younger than 60 years old, as well as those with concomitant stroke or cardiovascular diseases, an elevated TyG index is associated with adverse short-term and long-term outcomes. Furthermore, in non-diabetic patients, an elevated TyG index is associated with adverse long-term prognosis.
Study context
- Population
- Patients requiring trauma/surgical ICU admission, MIMIC-IV database
- Participants
- 2,103 patients
- Exposure
- Elevated vs lower TyG index
- Outcome
- 28-day mortality and 180-day mortality
- Follow-up
- 28 days and 180 days
Methodological detailsMIMIC-IV database, TyG index tertiles
- MIMIC-IV database
- TyG index tertiles
Main finding
As reported in the abstract
Mortality per elevated TyG index
Elevated TyG indexAdjusted hazard ratio (95% CI)
28-day mortality
1.19(1.04–1.37)
180-day mortality
1.24(1.11–1.39)
Per elevated TyG index, as printed
- 28-day mortality rate (whole cohort)
- 18%
- 180-day mortality rate (whole cohort)
- 24%
Observational data: associations, not effects.
Further findings
Subgroups: age <60 years, concomitant stroke or CVD · 28 days and 180 days
- Elevated TyG index associated with increased 28-day and 180-day mortality
Subgroup: nondiabetic patients · 180 days
- Elevated TyG index associated with 180-day mortality
Original publication
Association of the TyG index with prognosis in surgical intensive care patients: data from the MIMIC-IV. Cardiovasc Diabetol. Published 6 June 2024. doi:10.
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