Association of shift work with oxidative stress and alteration of fasting plasma glucose level in Chinese adults
Authors' conclusion
These findings suggest that shift work is positively associated with blood glucose, and the association is partially mediated by oxidative stress.
Study context
- Population
- Chinese adults
- Participants
- 831 adults
- Exposure
- Shift work vs no shift work
- Outcome
- Association of shift work with blood glucose (FPG) and mediating role of oxidative stress
Main finding
As reported in the abstract
Each group vs without shift workPercentage change in FPG, % (95% CI)
Three-shift work
6.49(4.21%–8.83%)
Each group vs without shift workEstimate (95% CI)
Three-shift work
OR for impaired fasting glucose 1.886(1.114–3.192)
Three-shift work
OR for AGR 1.929(1.197–3.111)
- Positive dose-response between shift work duration and fasting plasma glucose (FPG)
- P for trend < 0.001
- Positive dose-response between shift work duration and abnormal glucose regulation (AGR)
- P for trend = 0.035
Observational data: associations, not effects.
Further findings
Oxidative stress biomarkers
- Dose-response between shift work duration and 8-OHdG
- P for trend = 0.002
- Dose-response between shift work duration and 8-isoPGF2α
- P for trend = 0.019
- Urinary 8-OHdG and 8-isoPGF2α partially mediated association of shift work duration with FPG, IFG and AGR; mediating proportions
- 4.77% to 20.76%
Original publication
Association of shift work with oxidative stress and alteration of fasting plasma glucose level in Chinese adults. Obesity (Silver Spring). Published 19 September 2023. doi:10.
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