Association of Serum 25-Hydroxyvitamin D With Stroke: Observational Mediation and Mendelian Randomization Study
Authors' conclusion
Higher 25(OH)D levels are linked to reduced stroke risk, potentially mediated by hypertension. Prioritizing blood pressure management may improve stroke prevention in 25(OH)D-deficient patients.
Study context
- Population
- Chin-Shan Community Cardiovascular Cohort participants with serum 25(OH)D data, 1990 to December 2011
- Participants
- 1,778 participants
- Exposure
- Higher vs lower serum 25D concentration
- Outcome
- Stroke (ischemic stroke in the 2-sample MR study)
- Follow-up
- 12 years
Methodological detailscommunity-based, external validation using 2-sample Mendelian randomization (MR), mediation analysis
- Community-based
- External validation using 2-sample MR
- Mediation analysis
Main finding
As reported in the abstract
Stroke risk with higher 25(OH)D · Over 12 years (21 598 person-years)
Developed stroke
163 participants
9.17%
HR for stroke, higher 25(OH)D
0.64
95% CI 0.43–0.96
Observational data: associations, not effects.
Further findings
Mediation by hypertension
- Mediation percentage, unadjusted models (P = .008)
- 23.3%
- Mediation percentage, full models (P = .072; nonsignificant)
- 15.5%
Ischemic stroke with genetically determined 25(OH)D (2-sample MR)
- Inverse variance weighted OR
- 0.92 (95% CI 0.85-0.99; P = .036)
- Hypertension had an insignificant mediating role in the MR study
Original publication
Association of Serum 25-Hydroxyvitamin D With Stroke: Observational Mediation and Mendelian Randomization Study. J Clin Endocrinol Metab. Published 14 August 2024. doi:10.
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