Association of prior treatment with nitrogen-containing bisphosphonates on outcomes of COVID-19 positive patients
Authors' conclusion
Among older COVID-19 patients, prior exposure to N-BP including ZOL was not associated with a reduction in ICU admission, ventilator use, or death.
Study context
- Population
- Individuals aged >50 years with a diagnosis of COVID-19, PCORnet Common Data Model, 4 academic medical centers, through 1 September 2021COVID-19 patients identified
- Participants
- 76,223 individuals
- Exposure
- Prior N-BP use vs no prior N-BP use
- N-BPn = 1,853
- Outcome
- Composite of:
- Intensive care unit (ICU) admission
- Ventilator use
- Death
- Follow-up
- 15, 30 and 180 days of COVID-19 diagnosis
Methodological detailsmulticentre, propensity-score matched 1:1
- Multicentre
- Propensity-score matched 1:1
Main finding
As reported in the abstract
15, 30 and 180 days
N-BP vs No N-BPHazard ratio (95% CI)
15 days
1.22(0.89–1.67)
30 days
1.24(0.93–1.66)
180 days
1.17(0.93–1.48)
Observational data: associations, not effects.
Further findings
- No significant differences in outcomes with ZOL (n=559) vs oral N-BP
Original publication
Association of prior treatment with nitrogen-containing bisphosphonates on outcomes of COVID-19 positive patients. Osteoporos Int. Published 13 September 2023. doi:10.
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