Association of prediabetes progression and regression with cognitive decline: Findings from the China Health and Retirement Longitudinal Study (CHARLS)
Main finding · Change in episodic memoryResult — go to the resultβ −0.11 95% CI −0.22 to 0.003Authors' conclusion
In people with prediabetes, progression to diabetes may be associated with accelerated cognitive decline but regression to normoglycaemia does not retard cognitive decline. Prediabetes progression and regression may not be predictive of change in cognitive function.
Study context
- Population
- Adults with prediabetes (ADA criteria) in the China Health and Retirement Longitudinal Study (CHARLS); 56% women, mean age 58.6 ± 8.4 yearswith prediabetes
- Participants
- 2,590 adults
- Exposure
- Prediabetes progression or regression vs remaining prediabetes
- Remained normoglycaemian = 858
- Outcome
- Change in cognitive function (standardized total score, episodic memory and mental status)
- Follow-up
- 2011 to 2015 and 2015 to 2018
Methodological detailsthree waves (2011, 2015 and 2018)
- Three waves (2011, 2015 and 2018)
Main finding
Change in episodic memory · 2011 to 2015
β
−0.11
95% CI −0.22 to 0.003
P = 0.057
Change by group
Progressed to diabetes
12%
Regressed to normoglycaemia
41%
As reported in the abstract
Observational data: associations, not effects.
Further findings
Change in cognitive function 2015 to 2018
- Neither prediabetes progression nor regression predicted change in cognitive function
Remained normoglycaemia (separate group, n = 858) vs remained prediabetes · 2011 to 2015 and 2015 to 2018
- Changes in cognitive function similar to those who remained prediabetes
Original publication
Association of prediabetes progression and regression with cognitive decline: Findings from the CHARLS. Diabet Med. Published 23 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →