Comparison of SGLT2 inhibitors with DPP-4 inhibitors combined with metformin in patients with acute myocardial infarction and diabetes mellitus
An erratum to this article was published (Cardiovasc Diabetol, 5 Sep 2023 ↗)
Main finding · MACEResult — go to the resultHazard ratio 0.99 95% CI 0.46–2.14Authors' conclusion
Our findings demonstrated that SGLT2i did not influence the rate of MACEs compared with DPP-4i in combination with metformin in diabetic patients with AMI but did improve left ventricular ejection fraction.
Study context
- Population
- Diabetic patients with acute MI from a Korean nationwide multicenter observational cohort
- Participants
- 779 patients
- Exposure
- Metformin plus SGLT2i vs metformin plus DPP-4i
- SGLT2in = 186
- DPP-4in = 593reference
- Outcome
- MACE: composite of all-cause mortality, non-fatal MI, any revascularization, cerebrovascular accident and stent thrombosis
- Follow-up
- One year
Methodological detailsnationwide multicenter, inverse probability of treatment weighting (IPTW)
- Nationwide multicenter
- Inverse probability of treatment weighting (IPTW)
Main finding
MACE
Hazard ratio
0.99
95% CI 0.46–2.14
P = 0.983
SGLT2ivs DPP-4i
HR 0.99 (95% CI 0.46–2.14); P = 0.983
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | SGLT2i | DPP-4i | P value |
|---|---|---|---|
| Left ventricular ejection fraction improvement (exploratory), before statistical balancingExploratory analysis | 6.10 ± 8.30 | 2.95 ± 10.34 | P = 0.007 |
| Left ventricular ejection fraction improvement (exploratory), after IPTWExploratory analysis | 6.91 ± 8.91 | 3.13 ± 10.41 | P = 0.027 |
All clinical outcome items
- All items for clinical outcomes comparable between the two groups in unadjusted and adjusted analyses
Original publication
Comparison of SGLT2 inhibitors with DPP-4 inhibitors combined with metformin in patients with acute myocardial infarction and diabetes mellitus. Cardiovasc Diabetol. Published 22 July 2023. doi:10.
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