Association of plasma chemerin with all-cause and disease-specific mortality – results from a population-based study
Authors' conclusion
The present study detected a positive association between plasma chemerin concentrations and all-cause mortality in a large population-based study sample. Cause-specific analyses have shown that chemerin is likely to play a decisive role in cancer-related deaths. However, a direct association with cardiovascular mortality could not be established.
Study context
- Population
- General population, two independent cohorts of the Study of Health in Pomerania (SHIP)two cohorts
- Participants
- 3,037 vs 4,193
- Exposure
- Plasma chemerin concentration
- SHIP-START-1n = 3,037
- SHIP-TREND-0n = 4,193
- Outcome
- All-cause mortality
- Follow-up
- Median 15 and 9 years, respectively
Methodological detailstwo independent cohorts, multivariable Cox proportional hazard regression, competing events considered
- Two independent cohorts
- Multivariable Cox proportional hazard regression
- Competing events considered
Main finding
As reported in the abstract
Higher risk of all-cause mortality per 30 ng/mL increase in chemerin (95% CI 1.10-1.26), independent of major confounders
17%
Deaths during follow-up in SHIP-START-1
507
Deaths during follow-up in SHIP-TREND-0
208
Observational data: associations, not effects.
Further findings
Cause-specific mortality (cancer, cardiovascular disease (CVD))
- Chemerin significantly associated with cancer mortality
- Chemerin not associated with CVD mortality
- Competing events considered
Original publication
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