Association of obesity with cardiovascular disease in the absence of traditional risk factors
Authors' conclusion
We found that obesity increased the risk of CVD in people without traditional CVD risk factors. The association of WHtR with CVD was stronger in people under 60 years old.
Study context
- Population
- People without traditional cardiovascular disease (CVD) risk factors, Kailuan cohort; men 63.99%, mean age 48.14 ± 3.33 years1,298 CVD cases
- Participants
- 31,955 people
- Exposure
- Obesity vs normal body mass index (BMI) / waist height ratio (WHtR) non-obese
- Outcome
- CVD and its subtypes (stroke, myocardial infarction (MI))
- Follow-up
- Median 12.97 (IQR 12.68-13.17) years
Methodological detailsKailuan cohort, multivariate Cox proportional hazard models
- Kailuan cohort
- Multivariate Cox proportional hazard models
Main finding
As reported in the abstract
CVD · median 12.97 years
Hazard ratio (95% CI)
BMI obesevs Normal BMI
1.31(1.11–1.55)
WHtR obesevs WHtR non-obese
1.25(1.11–1.41)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| StrokeBMI obesevs Normal BMI | 1.21 (1.01–1.46) | ||
| StrokeWHtR obesevs WHtR non-obese | 1.18 (1.03–1.34) | ||
| MIBMI obesevs Normal BMI | 1.62 (1.13–2.33) | ||
| MIWHtR obesevs WHtR non-obese | 1.57 (1.18–2.09) | ||
| CVD by WHtR, age <60 yearsWHtR obesevs WHtR non-obeseAge × WHtR interaction | 1.44 (1.24–1.67) | P for interaction was 0.043 | |
| 0.512Hazard ratio (log scale) |
CVD by WHtR, age <60 years
- Association between WHtR and CVD stronger in people under 60 years old
Original publication
Association of obesity with cardiovascular disease in the absence of traditional risk factors. Int J Obes (Lond). Published 8 November 2023. doi:10.
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