Association of life’s essential 8 with cardiovascular outcomes and mortality in adults with prediabetes: mediating role of inflammatory biomarkers
Authors' conclusion
Achieving optimal LE8 metrics is significantly associated with reduced cardiovascular risk and mortality in people with prediabetes, and systemic inflammation partially explains these associations.
Study context
- Population
- Adults with prediabetes, UK Biobank
- Participants
- 33,745 adults
- Exposure
- Higher vs lower LE8 score
- Outcome
- CVD incidence, CVD mortality and all-cause mortality
Methodological detailsUK Biobank, multivariable Cox proportional hazards regression, mediation analysis
- UK Biobank
- Multivariable Cox proportional hazards regression
- Mediation analysis
Main finding
As reported in the abstract
Higher LE8 score vs CVD incidence, CVD mortality, all-cause mortality
Higher LE8 scoreHazard ratio (95% CI)
CVD incidence; multivariable-adjusted
0.49(0.45–0.53)
CVD mortality; multivariable-adjusted
0.46(0.35–0.61)
All-cause mortality; multivariable-adjusted
0.54(0.48–0.60)
Observational data: associations, not effects.
Further findings
Mediation by inflammatory biomarkers (neutrophil count)
- Neutrophil count mediated LE8-CVD association
- 9.65%
- Neutrophil count mediated LE8-mortality association
- 17.20%
Genetic susceptibility (PRS groups)
- LE8 adherence associated with lower cardiovascular risk across all PRS groups
- P for interaction > 0.05
Original publication
Association of life’s essential 8 with cardiovascular outcomes and mortality in adults with prediabetes: mediating role of inflammatory biomarkers. Diabetes Res Clin Pract. Published 23 February 2026. doi:10.
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