Association of intestinal microbiota and its metabolite markers with excess weight in Chinese children and adolescents
Authors' conclusion
This study identified intestinal microbiota and metabolic markers associated with excess weight in Chinese children.
Study context
- Population
- Chinese children aged 6–14 years from three boarding schoolsmetabolomics in 10 vs 10
- Participants
- 163 children
- Exposure
- Overweight/obesity vs normal weight
- Normal-weightn = 72reference
- Overweight/obesityn = 91
- Outcome
- Intestinal microbiota and faecal metabolic biomarkers associated with excess weight
Methodological detailsthree boarding schools, metabolomics subsample matched 1:1 for school, sex and age
- Three boarding schools
- Metabolomics subsample matched 1:1 for school, sex and age
Main finding
As reported in the abstract
Intestinal microbiota (16S rRNA sequencing)
- Alpha diversity significantly higher in normal-weight vs overweight/obese
- Significant difference in microbial community structure between groups (PCoA, PERMANOVA)
- Relative abundances of Megamonas, Bifidobacterium and Alistipes differed significantly
Observational data: associations, not effects.
Further findings
Faecal metabolomics (10 normal-weight vs 10 obesity)
- Differential metabolites associated with obesity
- 14
- Main differential metabolic pathways associated with obesity
- 2
Original publication
Association of intestinal microbiota and its metabolite markers with excess weight in Chinese children and adolescents. Pediatr Obes. Published 6 March 2023. doi:10.
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