Association of glycemic variability and prognosis in patients with traumatic brain injury: A retrospective study from the MIMIC-IV database
Authors' conclusion
Higher GV is related to poorer consciousness outcomes and increased risk of in-hospital death in ICU patients with TBI. Additional research is needed to understand the logical relationship between GV and TBI progression.
Study context
- Population
- Intensive care unit (ICU) patients with traumatic brain injury (TBI), MIMIC-IV database
- Participants
- 1,641 patients
- Exposure
- Higher vs lower glycaemic variability
- Outcome
- Discharge GCS by CV
Methodological detailsMIMIC-IV database
- MIMIC-IV database
Main finding
As reported in the abstract
Higher coefficient of variation (CV) associated with lower discharge Glasgow Coma Scale (GCS), multivariable linear regression β
−1.86 (−3.08 ∼ −0.65), P = 0.003 (95 %CI)
Observational data: associations, not effects.
Further findings
- CV ≥ 0.3 risk factor for in-hospital death, multivariable COX HR
- 1.74 (1.15-2.62), P = 0.003 (95 %CI)
- Consistent across sensitivity and subgroup analyses
Original publication
Association of glycemic variability and prognosis in patients with traumatic brain injury: A retrospective study from the MIMIC-IV database. Diabetes Res Clin Pract. Published 26 September 2024. doi:10.
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