Gestational diabetes & diabetes in pregnancy
Association of Gestational Diabetes Mellitus Complicated With Short Sleep Duration and Child Neurodevelopmental Delay
Main finding · Child neurodevelopmental delayResult — go to the resultHazard ratio 1.58 95% CI 1.03–2.44Authors' conclusion
GDM complicated with SSD was associated with increased risk for child neurodevelopmental delay by enhancing the intergenerational association of maternal-fetal glucose metabolism disorder.
Study context
- Population
- Mother-child pairs; Gestational diabetes mellitus (GDM) by 75-g OGTT at 24–28 weeks; self-reported sleep duration (Pittsburgh Sleep Quality Index) in second and third trimesters
- Participants
- 7,069 mother-child pairs
- Exposure
- GDM + short sleep duration (SSD) vs unexposed
- Outcome
- Child neurodevelopmental delay (Denver Developmental Screening Test-II and Gesell Development Diagnosis Scale)
- Follow-up
- 6 to 36 months postpartum
Main finding
Child neurodevelopmental delay
Hazard ratio
1.58
95% CI 1.03–2.44
GDM + SSDvs Unexposed
HR 1.58 (95% CI 1.03–2.44)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Maternal-fetal glucose metabolic disorder
- GDM + SSD associated with the greatest risks of maternal-fetal glucose metabolic disorder
Cord blood C-peptide (per IQR increase, 0.58 mmol/L) and child neurodevelopmental delay
- HR (95% CI) per interquartile increase in cord blood C-peptide
- 1.28 [1.12-1.48]
Mediation by C-peptide of GDM + SSD and child neurodevelopmental delay
- Proportion mediated by C-peptide
- 14.4%
- Stronger linear association of maternal glucose metabolism profiles and C-peptide in GDM + SSD
Original publication
Association of Gestational Diabetes Mellitus Complicated With Short Sleep Duration and Child Neurodevelopmental Delay. J Clin Endocrinol Metab. Published 29 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →