Association of insulin resistance and glycemic measures with major abnormal electrocardiogram in older Chinese: Cross-sectional analysis based on the Guangzhou Biobank Cohort study
Authors' conclusion
IR and glycemic measures were associated with MA-ECG, ischemia and prolonged QTc in older Chinese, especially in women, those with obesity, and those with diabetes. These findings underscore the importance of regular evaluations for these groups.
Study context
- Population
- Adults aged ≥50 years without CVD, Guangzhou Biobank Cohort Study; mean age 61.6 (SD 7.1) years5,918 men
- Participants
- 21,720 adults
- Outcome
- Major abnormal ECG (MA-ECG) and its specific abnormalities
Main finding
As reported in the abstract
- Ln-fasting insulin and major abnormal electrocardiogram (MA-ECG), aOR
- 1.52 (1.15-2.02) (95% CI)
- Ln-fasting insulin and ST-T abnormalities, aOR
- 1.83 (1.37-2.45) (95% CI)
- TyG index and MA-ECG, aOR
- 1.08 (1.04-1.13) (95% CI)
- TyG index and ST-T abnormalities, aOR
- 1.16 (1.11-1.22) (95% CI)
- Ln-fasting insulin and Q wave abnormalities, aOR
- 3.19 (1.52-6.67) (95% CI)
Observational data: associations, not effects.
Further findings
TyG index and prolonged QTc, by sex and obesity
- Association varied by sex and obesity
- P for interaction ≤ 0.01
Ln-fasting plasma glucose and ECG abnormalities, by diabetes
- Stronger associations in participants with diabetes than those without
Original publication
Association of insulin resistance and glycemic measures with major abnormal electrocardiogram in older Chinese: Cross-sectional analysis based on the Guangzhou Biobank Cohort study. Diabetes Res Clin Pract. Published 7 December 2023. doi:10.
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