Association of estimated glomerular filtration rate (eGFR) slope with all-cause mortality, macrovascular and microvascular outcomes in people with type 2 diabetes and early-stage chronic kidney disease
Main finding · All adverse outcomesResult — go to the resultAdjusted hazard ratio 1.36 to 2.97Authors' conclusion
In a cohort of T2D people without decreased eGFR, accelerated declines and increases in eGFR were associated with all-cause mortality, macrovascular and microvascular complications, supporting the potential prognostic utility of eGFR slope in T2D people with early-stage CKD.
Study context
- Population
- T2D participants without decreased eGFR (>60 mL/min/1.73 m²), 2008–2015, Hong Kong Hospital Authority electronic database
- Participants
- 115,139 participants
- Exposure
- eGFR slope quintiles vs Quintile 3
- Outcome
- All-cause mortality, macrovascular and microvascular complications
- Follow-up
- Median 7.8 years
Methodological detailspopulation-based electronic database, Cox proportional or cause-specific models
- Population-based electronic database
- Cox proportional or cause-specific models
Main finding
All adverse outcomes
Adjusted hazard ratio
1.36 to 2.97
all P < 0.0001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Quintile 5 vs Quintile 3: CKD, ≥40% eGFR decline, death, CVD, DR, DN · median follow-up 7.8 yearsQuintile 5vs Quintile 3 | aHR (CKD) 0.65 (95 % CI 0.63–0.67) | |
| Quintile 5 vs Quintile 3: CKD, ≥40% eGFR decline, death, CVD, DR, DN · median follow-up 7.8 yearsQuintile 5vs Quintile 3 | aHR (≥ 40 % decline in eGFR) 0.85 (95 % CI 0.82–0.89) | |
| Quintile 5 vs Quintile 3: CKD, ≥40% eGFR decline, death, CVD, DR, DN · median follow-up 7.8 yearsQuintile 5vs Quintile 3 | aHR (death) 1.48 (95 % CI 1.40–1.56) | |
| Quintile 5 vs Quintile 3: CKD, ≥40% eGFR decline, death, CVD, DR, DN · median follow-up 7.8 yearsQuintile 5vs Quintile 3 | aHR (CVD) 1.19 (95 % CI 1.14–1.25) | |
| Quintile 5 vs Quintile 3: CKD, ≥40% eGFR decline, death, CVD, DR, DN · median follow-up 7.8 yearsQuintile 5vs Quintile 3 | aHR (DR) 1.07 (95 % CI 1.004–1.15) | |
| Quintile 5 vs Quintile 3: CKD, ≥40% eGFR decline, death, CVD, DR, DN · median follow-up 7.8 yearsQuintile 5vs Quintile 3 | aHR (DN) 1.62 (95 % CI 1.37–1.91) | |
| 0.512Ratio (log scale) |
Original publication
Association of eGFR slope with all-cause mortality, macrovascular and microvascular outcomes in people with type 2 diabetes and early-stage chronic kidney disease. Diabetes Res Clin Pract. Published 30 September 2023. doi:10.
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