Association between “urological age” with metabolic syndrome in non-pregnant adult women: potential mediating role of depression
Authors' conclusion
UA and UAA may increase the risk of MetS in non-pregnant adult women. Furthermore, Depressive symptoms partially mediated the relationship between UA/UAA and MetS.
Study context
- Population
- Nonpregnant women aged ≥20 years with full data, National Health and Nutrition Examination Survey (NHANES)
- Participants
- 8,354 women
- Exposure
- Urological age and urological age acceleration and metabolic syndrome (MetS)
- Outcome
- Metabolic syndrome (MetS)
Methodological detailsNHANES data, logistic regression, ROC curve analysis, mediation analysis
- NHANES data
- Logistic regression
- ROC curve analysis
- Mediation analysis
Main finding
As reported in the abstract
MetS
| Group | AUC | Sensitivity | Specificity |
|---|---|---|---|
| Urological age (UA) | 0.728 (95 % CI: 0.716-0.740) | 77.56 % | 58.33 % |
| Urological age acceleration (UAA) | 0.640 (95 % CI: 0.626-0.654) | 48.92 % | 73.60 % |
AUC
Urological age (UA)0.728 (95 % CI: 0.716-0.740)
Urological age acceleration (UAA)0.640 (95 % CI: 0.626-0.654)
Sensitivity
Urological age (UA)77.56 %
Urological age acceleration (UAA)48.92 %
Specificity
Urological age (UA)58.33 %
Urological age acceleration (UAA)73.60 %
Observational data: associations, not effects.
Further findings
| Outcome | UA | UAA |
|---|---|---|
| Mediation by depression of UA/UAA–MetS association | ||
| Proportion of mediation | 0.0405, 95 %CI: (0.0208, 0.01); P-value < 0.001 | 0.0419, 95 %CI: (0.0214, 0.06,); P-value < 0.001 |
- Mediation by depression of UA/UAA–MetS association: depression assessed by PHQ-9
Original publication
Association between “urological age” with metabolic syndrome in non-pregnant adult women: potential mediating role of depression. Diabetes Res Clin Pract. Published 17 November 2025. doi:10.
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