Association Between Urinary Phthalate Metabolites and Sarcopenia in US Adults From National Health and Nutrition Examination Survey (NHANES) 2011-2018
Authors' conclusion
This study provides new evidence that co-exposure to phthalates might increase the risk of sarcopenia. Further research is needed to explore the causal relationship between phthalate metabolites and sarcopenia, as well as to elucidate the underlying mechanisms involved.
Study context
- Population
- US adults, NHANES 2011–2018
- Participants
- 3,536 adults
- Exposure
- Urinary phthalate metabolite exposure and sarcopenia
- Outcome
- Sarcopenia
Methodological detailsNHANES 2011–2018, multivariable logistic regression, RCS, WQS, qgcomp and Bayesian kernel machine regression (BKMR) models
- NHANES 2011–2018
- Multivariable logistic regression
- RCS, WQS, qgcomp and BKMR models
Main finding
As reported in the abstract
- Monobutyl phthalate (MBP), monoethyl phthalate (MEP) and mono-isobutyl phthalate (MiBP) positively associated with sarcopenia after covariate adjustment
- P < .05
Observational data: associations, not effects.
Further findings
Sarcopenia, subgroup by age
- Stronger associations among individuals aged 20-40 years
Interactions between metabolites
- BKMR revealed potential interaction effects between mono(3-carboxypropyl) phthalate, mono-2-ethyl-5-carboxypentyl phthalate, MBP and MEP on sarcopenia risk
Original publication
Association Between Urinary Phthalate Metabolites and Sarcopenia in US Adults From NHANES 2011-2018. J Clin Endocrinol Metab. Published 9 January 2025. doi:10.
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