Association between triglyceride–glucose muscle-loss index (TyG–MLI) and incident cardiovascular disease: a prospective cohort study in the UK biobank
Main finding · Incident CVDResult — go to the resultHazard ratio 1.48 95% CI 1.44–1.53Authors' conclusion
TyG-MLI, a composite marker reflecting insulin resistance and muscle loss, was independently associated with incident CVD in this large population-based cohort. These findings suggest that TyG-MLI captures cardiometabolic risk beyond traditional measures and may be particularly informative in individuals without obesity.
Study context
- Population
- UK Biobank participants free of cardiovascular disease (CVD) at baseline
- Participants
- 277,418 participants
- Exposure
- Higher vs lower TyG-MLI
- Outcome
- Incident CVD (hospital admissions and death registries)
- Follow-up
- Median 15.1 years
Methodological detailspopulation-based, UK Biobank
- Population-based
- UK Biobank
Main finding
Incident CVD · median 15.1 years
Hazard ratio
1.48
95% CI 1.44–1.53
Q4vs Q1
HR 1.48 (95% CI 1.44–1.53)
As reported in the abstract
- HR per 1-SD higher TyG-MLI
- 1.17 (95% CI 1.16-1.18)
- Participants who developed CVD
- 40,398
- Crude CVD incidence increased across TyG-MLI quartiles; Kaplan-Meier log-rank
- P < 0.001
Observational data: associations, not effects.
Further findings
Dose-response (restricted cubic spline)
- Non-linear association across the TyG-MLI distribution
Sensitivity analyses
- Consistent results
BMI-stratified analyses
- TyG-MLI showed stronger associations with CVD than TyG index, particularly in normal-weight and underweight individuals
Original publication
Association between triglyceride–glucose muscle-loss index (TyG–MLI) and incident cardiovascular disease: a prospective cohort study in the UK biobank. Cardiovasc Diabetol. Published 13 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →